AFJOG

African Journal of Obstetrics and Gynaecology | Volume 2 | Issue 2 | 2024 | 35 CASE REPORT African Journal of Obstetrics and Gynaecology | Volume 2 | Issue 2 | 2024 | Polycystic Ovary Syndrome: An update from the 2023 international guideline CONCLUSION Clinicians should be aware of potential interferences with steroid bioassays and should consider their clinical acumen and judgement for diagnosis and treatment decisions, particularly in atypical presentations. Radioimmunoassays are subject to interference and may thus present spurious results. Individuals with disorders of sex differentiation should be managed by a multidisciplinary team with a clear long term plan of management. The patient should always possess explanatory medical documentation. List of abbreviations: 3βHSD2: 3β-hydroxysteroid dehydrogenase type 2 11βHD: 11β-hydroxylase deficiency 17-OHP: 17α- hydroxyprogesterone 21OHD: 21-hydroxylase deficiency ACTH: Adrenocorticotrophic hormone CAH: Congenital Adrenal Hyperplasia DHEAS: dehydroepiandrosterone sulphate HDHE: high dose hook effect LC-MS/MS: Liquid Chromatography- Mass Spectrometry/ Mass spectrometry RIA: radioimmunnoassay Consent for Publication: Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Availability of data and material: All relevant clinical data and images are included in this report. Any additional information is available from the authors following reasonable request. Competing interests: The authors have no competing interests to declare Funding: There is no external funding to declare for this publication Author’s Contribution: RM, was involved in case management, data collection and preparing the manuscript. MP, MM were involved in management of the case and reviewing the manuscript. All authors approved the final draft of the manuscript. Acknowledgements: D Van der Westhuizen (Registrar in Department of Chemical Pathology, Groote Schuur Hospital University of Cape Town), Ian Ross (Endocrinology Professor, Groote Schuur Hospital, University of Cape Town) REFERENCES ¥ ¥ ¤ ¥ ¥ ¥ ¡ ¥ ¥ µ © ¥ ¥ ¤ ¥ ¦ ¥ ¶ ¬ ® ¬ ® ¶¶ ¥ ¤ ¤ ¥ ¡ ¡ ¤ ¡ ¤ β ¥ β ¥ ¤ ¥ § ¦ ¤ ¥