AFJOG

African Journal of Obstetrics and Gynaecology | Volume 2 | Issue 2 | 2024 | 52 African Journal of Obstetrics and Gynaecology | Volume 2 | Issue 2 | 2024 | Abstracts AFJOG ABSTRACTS Hospital from January 2018 to December 2022. Tygerberg Hospital serves low and middle socio-economic, and high- risk obstetric populations. After the Stellenbosch University Ethics Committee approved the study, pregnant women who underwent transvaginal cervical cerclage were identified from the hospital's theatre records, and data was collected from the hospital's electronic health records. We included all cases for whom delivery outcomes were available. Results: There were 93 women treated with a transvaginal cerclage for whom the delivery outcomes were available. The median gestational age at delivery was 32 weeks (IQR 25- 37). Forty-six (49%) women had a body mass index ≥ 30kg/ m2. Fifty-four (58%) women had no prior viable pregnancies, and 86 (92%) had at least one previous second-trimester miscarriage. The main indications for cerclage were history- indicated (HI) 62 (64%), ultrasound-indicated (UI) 13 (14%), and emergency (EC) 18 (19%) cerclages. Following cerclage, there were 67 (72%) livebirths from 47 (76%) HI, 12 (67%) EC, and 8 (62%) UI cerclages, 64 (69%) reached 27 weeks and beyond. Twenty-two (24%) second-trimester losses and four stillbirths. There was one case of ruptured membranes within 24 hours of a HI cerclage placement that resulted in a miscarriage at 15 weeks gestation. The median gestational age at delivery for women with a HI cerclage was 33 (IQR 27-37) weeks, and for EC 28 (IQR 24 -36) weeks and UI 28 (IQR 24-35) weeks. The median birth weight was 2322g (IQR 1127-2939g), with HI 2370g (IQR 1270-2942g) EI 2155g (IQR 1150-2890g) and UI 1585g (IQR 813-3000g). Conclusion: In this low and middle-resource setting, transvaginal cerclage for history-, ultrasound, and even emergency indications, enabled almost three-quarters of jeopardized pregnancies to progress well beyond viability. ABSTRACTTITLE: 334: Assessment of the impact of radical hysterectomy for early cervical cancer on lower urinary tract function: a pilot study. AUTHORS: Dr Quinton Blignaut qblignaut@gmail.com Quinton Blignaut 1 , Zeelha Abdool 1 , Leon Snyman 2 1 University of Pretoria ,Steve Biko Academic Hospital 2 University of Pretoria, Kalafong Academic Hospital Introduction: Cervical cancer is the third most common cancer in women, with a global incidence of 13,1 per 100 000 women [1]. A radical hysterectomy is indicated for cervical cancer (FIGO) stages IA2-IIA but is however associated with lower urinary tract symptoms (LUTS) as a result of damage to pelvic autonomic nerves with the resultant alteration in bladder function i.e., capacity and contractility [2,3]. Methods: This was a retrospective cohort study including women who received a radical hysterectomy for early cervical cancer at two state hospitals in South Africa between January 2019 and December 2021. After obtaining ethical clearance participants were identified using hospital records and telephonic surveys were conducted to answer the validated questionnaires. Data was analysed using IBM SPSS Statistics V28 software. Scores were compared to determine whether there was a significant difference between baseline, at 6 and 12 months respectively. Limitation is recall bias. Results: UDI6 scores increased significantly from 10.24 (at baseline) to 22.02 at the 6-month post-operation review (p < 0.001), then decreased significantly from the 6-month post operation review to 16 at the 12-month post-operation review (p < 0.001), but was still significantly higher compared to the score at pre-operation point (p = 0.002). The IIQ7 scores increased significantly from3.39 (at baseline) to 15.66 at the 6-month post-operation review (p < 0.001), then decreased significantly from the 6-month post-operation review to 9.64 at the 12 month post-operation review (p < 0.001), but was still significantly higher compared to the score at pre-operation point (p < 0.001). SSI scores increased significantly from 0.65 (at baseline) to 2.27 at the 6-month post-operation review (p < 0.001) and decreased significantly from the 6-month post-operation review from 2.27 to 1.69 at the 12-month post-operation review (p < 0.001), but was still significantly higher at 1.69, compared to the pre-operation point (p < 0.001). Conclusion: We found a negative impact of radical hysterectomy on lower urinary tract function that is sustained at 12 months post-surgery. Improvement of symptoms between 6 months post-op and 12 months post-op suggest that the impact may be transient or perceived as ‘new normal’ during that time period. The benefit of the impact of nerve- sparing surgery on LUTS should be investigated prospectively.