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*CDC-CentersforDiseaseControlandPrevention;#AssociatedwithBV;†Vs.single500mgoraldoseofmetronidazole References: 1. Metrogel Approved package insert 31 August 2021. 2. Kingsburgh C, Strydom K-A. The aetiology, diagnosis and management of the vaginal discharge syndrome. AmpathChat 2020;66:1-4. 3. Pirotta, M, Fethers K, Bradshaw C. Bacterial vaginosis more questions than answers. Australian Family Physician June 2009; Vol. 38, No. 6. 4. Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines, 2015. MMWR / June 5, 2015 / Vol. 64 / No. 3. 5. Beigi R, Austin M, Meyn L, et al. Antimicrobial resistance associated with the treatment of bacterial vaginosis. Am J Obstet Gynecol 2004;191:1124-1129. 6. Weir CB, Le JK. Metronidazole [online] May 2019 [cited 27 May 2020]; Available from URL: https://www.ncbi.nlm.nih.gov/books/NBK539728/. 7. Agnew KJ, Hillier SL. The E ect of Treatment Regimens for Vaginitis and Cervicitis on Vaginal Colonization by Lactobacilli. Sex Transm Dis 1995;22(5): 269-273. 8. Austin MN, Beigi RH, Meyn LA, et al. Microbiologic Response to Treatment of Bacterial Vaginosis with Topical Clindamycin or Metronidazole. J Clin Microbiol 2005;43(9):4492–4497. 9. WainAM.MetronidazoleVaginalGel0.75%(MetroGeI-Vaginal®)ABriefReview.InfectDisObstetGynecol1998;6:3-7. Schedulingstatus: S2 Proprietaryname(anddosageform): G Composition: Metronidazole37.5mg/5g. Preservatives :Methylhydroxybenzoate0.08%,Propylhydroxybenzoate0.02%. Pharmacological ation: A 20.2.6 Antimicrobial: medicines against protozoa. Indications: MetroGel V is indicated for the treatment of bacterial vaginosis . Registration number: 33/20.2.6/0243. Nameand businessaddressof applicant: iNovaPharmaceuticals (Pty)Limited. Co. Reg. No. 1952/001640/07,15eRiley Road,Bedfordview. Tel. No. 011 0870000 .www.inovapharma.co.za.For fullprescribing information,refertothepackage insertasapprovedbytheSAHPRA(SouthAfricanHealthProductsRegulatoryAuthority).Further informationisavailableonrequestfrom iNovaPharmaceuticals.IN5021/25 vaginal gel metronidazole 0.75% EMPOWERINGWOMEN 2,3 4 5,6,7 5,6,8 9

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