SAGES Magazine

THE SOUTH AFRICAN GASTROENTEROLOGY REVIEW 2022 | VOLUME 20 | ISSUE 1 | 27 RESEARCH 8. Ford AC, Talley NJ, Spiegel BMR, Foxx-Orenstein AE, Schiller L, Quigley EMM, et al. Effect of fibre, antispasmodics, and pep- permint oil in the treatment of irritable bowel syndrome: System- atic review and meta-analysis. Bmj. 2008;337(7683):1388–92. 9. Steenkamp V, Stewart MJJ. Medicinal applications and toxico- logical activities of Aloe products. Pharm Biol. 2007;45(5):411– 20. 10. Langmead L, Makins RJ, Rampton DS. Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Aliment Pharmacol Ther. 2004 Mar;19(5):521–7. 11. Langmead L, Feakins RM, Goldthorpe S, Holt H, Tsironi E, De Silva A, et al. Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. Aliment Pharmacol Ther. 2004 Apr;19(7):739–47. 12. Størsrud S, Pontén I, Simrén M (2015), Storsrud S, Ponten I, Simren M, et al. A Pilot Study of the Effect of Aloe barbadensis Mill. Extract (AVH200®) in Patients with Irritable Bowel Syn- drome: a Randomized, Double-Blind, Placebo-Controlled Study. J Gastrointest Liver Dis [Internet]. 2015 Sep 1 [cited 2017 Nov 14];24(3):275–80. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/26405698 13. Davis K, Philpott S, Kumar D, Mendall M. Randomised dou- ble-blind placebo-controlled trial of aloe vera for irritable bowel syndrome. Int J Clin Pract [Internet]. 2006 Sep 2 [cited 2017 Nov 14];60(9):1080–6. Available from: http://doi.wiley . com/10.1111/j.1742-1241.2006.00980.x 14. Hutchings HAH, Wareham K, Baxter JNJ, Atherton P, King- ham JGC, Duane P, et al. A Randomised, Cross-Over, Place- bo-Controlled Study of Aloe vera in Patients with Irritable Bowel Syndrome: Effects on Patient Quality of Life. ISRN Gastroenterol [Internet]. 2011 [cited 2017 Nov 14];2011:206103. Available from: http://www.hindawi.com/journals/isrn/2011/206103/ 15. Jia G, Meng M Bin, Huang ZW, Qing X, Lei W, Yang XN, et al. Treatment of functional constipation with the Yun-chang cap- sule: A double-blind, randomized, placebo-controlled, dose-es- calation trial. J Gastroenterol Hepatol. 2010;25(3):487–93. 16. ODES HSSHS, Madar Z. A double-blind trial of a celandin, aloevera and psyllium laxative preparation in adult patients with constipation. Digestion [Internet]. 1991 Jun [cited 2018 Jul 8];49(2):65–71. Available from: https://www.karger.com/Article/ FullText/200705 17. Chandra Sekhar Singh Bhaludra, Rama Rao Bethapudi, Adharvana Chari Murugulla, Chakrapani Pullagummi, Thota Latha, Kandula Venkatesh, Arun Jyothi Bheemagani AP and ARR. Cultivation, Phytochemical Studies, Biological Activities and Medicinal Uses of Aloe ferox, Grandfather of Aloes an Important Amazing Medicinal Plant [Internet]. International Journal Of Pharmacology, 2013 Oct 1, Vol.9(7), pp.405- 415; 2013. Available from: https://scialert.net/archivedetails. php?issn=1811-7775&issueno=58 18. Chang FY, Lu C-LL. Treatment of Irritable Bowel Syndrome Using Complementary and Alternative Medicine. J Chinese Med Assoc [Internet]. 2009 Jun [cited 2017 Nov 14];72(6):294–300. Available from: http://linkinghub.elsevier.com/retrieve/pii/ S1726490109703752 19. Cirillo C, Capasso R. Constipation and Botanical Medicines: An Overview. Phytother Res [Internet]. 2015 Oct [cited 2018 Jul 8];29(10):1488–93. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/26171992 20. Franz G. Plant laxatives. Indications for general practice . Dtsch Apotheker Zeitung [Internet]. 1992;132(33):1697–704. Available from: https://www.scopus.com/inward/record. uri?eid=2-s2.0-0026671688&partnerID=40&md5=9f03a- 67b569e5c708f8adfca5f848e5e 21. Flück H, Bubb WP. [A lamaistic prescription-formula for the treatment of chronic constipation]. Schweiz Rundsch Med Prax [Internet]. 1970 Aug 18 [cited 2019 Feb 7];59(33):1190–3. Available from: http://www.ncbi.nlm.nih.gov/pubmed/5528157 22. Gordon M, Jk M, Ce P, Ak A, Ag T. Osmotic and stimulant laxa- tives for the management of childhood constipation. Cochrane database Syst Rev [Internet]. 2012;7(8):CD009118. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22786523 23. HU Chun-sheng. Study on Facilitating Feces Excretion Function of Aloe Soft Capsule. Pract Prev Med [Internet]. 2009;3:114. Available from: http://en.cnki.com.cn/Article_en/CJFDTo- tal-SYYY200903114.htm 24. Hutcheon DA. The Efficacy and Safety of 4 Natural Products for the Management of IBS. Top Clin Nutr [Internet]. 2014 [cited 2018 Jul 8];29(2):113–22. Available from: http://content. wkhealth.com/linkback/openurl?sid=WKPTLP: landingpage& an=00008486-201404000-00003 25. Khedmat H, Karbasi A, Amini M, Aghaei A, Taheri S. Aloe vera in treatment of refractory irritable bowel syndrome: Trial on Iranian patients. J Res Med Sci [Internet]. 2013 Aug [cited 2017 Nov 14];18(8):732. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/24379854 26. Koch A. Investigations on the laxative action of aloin in the human colon. Planta Med. 1993;59(7 SUPPL.). 27. Jekat FW, Winterhoff H, Kemper FH. Anthraquinone drugs. Zeitschrift fur Phyther. 1990;11(6):177–84. 28. Koch A. Metabolizing of aloin. Correlation between in vitro and in vivo experiments . Dtsch Apotheker Zeitung [Internet]. 1995;135(13):34–6. Available from: https://www.scopus.com/ inward/record.uri?eid=2-s2.0-0028943523&partnerID=40&m- d5=7a1f428edf4f07e2bae0689a279e56f3 29. Kwon M, Ju SO. The effect of aloevera for constipation in schizophrenia patients. Indian J Sci Technol. 2016;9(41). 30. Liu JP, Yang M, Liu Y, Wei ML, Grimsgaard S. Herbal medicines for treatment of irritable bowel syndrome. Cochrane Database Syst Rev [Internet]. 2006 Jan 25 [cited 2018 Jul 24]; Available from: http://doi.wiley.com/10.1002/14651858.CD004116.pub2 31. Ma L, Zhang E. Constipation caused by antipsychotics treated by acupuncture and Compound Aloe Capsule for 30 cases [Internet]. Vol. 13, Chinese medicine modern distance educa- tion of china [zhong guo zhong yi yao xian dai yuan cheng jiao yu]. 2015. p. 76–7. Available from: http://cochranelibrary-wiley. com/o/cochrane/clcentral/articles/227/CN-01435227/frame.html 32. Melzig MF. Plant-based laxatives: Phytopharmaceuticals as laxatives . Pharm Unserer Zeit [Internet]. 2008;37(2):136–41. Available from: https://www.scopus.com/inward/record.uri?eid =2-s2.0-43349101449&doi=10.1002%2Fpauz.200700256&part- nerID=40&md5=f0312a4db108c75671cb789fcbd673f7 33. Störsrud S, Midenfjord I, Lindh A, Ringstrom G, Agerforz P, Jer- lstad P, et al. T1256 Aloe Vera-aPromising Treatment Option for Patients with Irritable Bowel Syndrome (IBS). Gastroenterology [Internet]. 2009;136(5):A-533. Available from: http://linkinghub. elsevier.com/retrieve/pii/S0016508509624513 34. Wintola OA, Otang WM, Afolayan AJ. The prevalence and per- ceived efficacy of medicinal plants used for stomach ailments in the Amathole District Municipality, Eastern Cape, South Africa. SOUTH AFRICAN J Bot. 2017 Jan;108:144–8. 35. Wiessner R. Irritable bowel syndrome: Regulatory treat- ment with a Tibetan medicine . Schweizerische Zeitschrift fur GanzheitsMedizin [Internet]. 2008;20(7–8):384. Avail- able from: https://www.scopus.com/inward/record. uri?eid=2-s2.0-57449092715&partnerID=40&md5=92d99155fd- 5164f2ba73fe185b5e9c8b 36. Zhang Zhao-Cui; Gao Hui-Zhi. Therapeutic effects of aloe-paste in the treatment of antipsychotic agents induced constipation. J Qilu Nurs [Internet]. 2004;06:1–4. Available from: http://en.cnki . com.cn/Article_en/CJFDTotal-QLHL200406015.htm 37. Sallon S, Ben-arye E, Davidson R, Shapiro H, Ginsberg G, Li- gumsky M. Original Paper : Functional Disorders A Novel Treat- ment for Constipation-Predominant Irritable Bowel Syndrome Using Padma ® Lax , a. 2002;161–71. 38. Dorn SD d., Kaptchuk TJ j., park JB b., Nguyen LT t., canen- guez K, Nam BH h., et al. A meta-analysis of the placebo response in complementary and alternative medicine trials of irritable bowel syndrome. 2007 Aug [cited 2018 Jul 8];19(Octo- ber 2006):630–7. Available from: http://doi.wiley.com/10.1111/ j.1365-2982.2007.00937.x