SAGES Magazine

THE SOUTH AFRICAN GASTROENTEROLOGY REVIEW 2022 | VOLUME 20 | ISSUE 2 | 37 SAGES CONGRESS 2022 ABSTRACTS the presence of the FA Complementation Group G gene mutation. Discussion Biliary Atresia, the commonest cause of neonatal cholestasis and end stage liver disease requiring transplant is most commonly an isolated finding. It is however, found in association with other congenital abnormalities affecting multiple organ systems and can be associated with congenitally acquired syndromes. Biliary Atresia has once been described in association with FA, an autosomal recessive disorder, that is both phenotypically and genotypically heterogenous. It is characterized by congenital malformations, hematological complications, and a significant predisposition to malignancies. We describe an African female with BA and severe pancytopenia with FA secondary to a FANCG mutation, the commonest FA causing mutation in the South African black population. POST COLONOSCOPY COLORECTAL CANCERS IN PRIVATELY INSURED PATIENTS IN SOUTH AFRICA. Author Dr Leony Fourie 1 , Prof. Damon Bizos 1 1 Wits University Introduction Post-Colonoscopy Colorectal Cancers (PCCRC) are the colorectal cancers (CRC) that are diagnosed within 3-5 years of a Colonoscopy where a cancer was not detected. The rate of PCCRC is an indicator of the quality of colonoscopy. Objective The primary objective of this study is to calculate the proportion of PCCRC in a privately insured population in South Africa and to describe the patient demographics and speciality of the doctor performing the colonoscopy. Method This is a retrospective population-based study. Data were obtained from the largest private health insurance company in South Africa. Patients diagnosed with CRC from the period of 1 January 2013 to 31 December 2019 were included. Patients with CRC who had undergone colonoscopy 6-60 months prior to the diagnosis of CRC were defined as PCCRC. Results A diagnosis of CRC was made in 19 538 patients in the 7- year period. Following exclusions, 4765 patients were included in this study for analysis. PCCRC was identified in 415 patients (8.72%) between 6-60 months, of whom 315 patients were identified between 6-36 months, PCCRC rate 6.61%. The median age (interquartile range, IQR) age in the overall study group presenting with CRC was 64 (53- 73) years, with that of the PCCRC group (n=415) being significantly higher at a median (IQR) age of 67 years when compared to the non-PCCRC group (n=4 350) of 64(53-72) years (P=0.0002). The gender ratio did not differ in the PCCRC group vs the non-PCCRC group. Rectal cancers were more likely to be present in the PCCRC group at 32.8% (n=136/415) vs non PCCRC group at 24%(n=1043/4350) (P<0.001). The PCCRC rate was 14% for gastroenterologists and 7.9% for surgeons. Conclusion This study is the first study from South Africa to analyse PCCRC. The PCCRC rate in this study is in line with published series. THE EPIDEMIOLOGICAL PROFILE OF GASTRIC CANCER PATIENTS IN GROOTE SCHUUR HOSPITAL CAPE TOWN, SOUTH AFRICA. Author Dr Innocent Ekparolaguaziba Francis 1 , Dr Galya Chinnery 2 , Dr Matt Scriba 2 , Prof Mashiko Setshedi 1 1 Medical Gastroenterology Unit, E floor, Groote Schuur Hospital, University of Cape Town., 2 Upper Gastro-Intestinal Surgery Unit, Groote Schuur Hospital, University of Cape Town Introduction According to the GLOBACOM 2018, gastric cancer remained the 5th most common cancer and the 3rd most common cause of cancer death. Among the strong factors associated with gastric cancer are H. Pylori infection diet and smoking. This study is therefore aimed at understanding the risk factors associated with gastric cancer in South Africa. Methods A retrospective cohort study to determine the epidemiological profile of patients diagnosed with gastric cancer (GCA) based on endoscopy and biopsy. Results Ninety patients were included with a mean age of 61 ± 11.7; 63.3% were males and the mean BMI was 21.67 ± 4.7. At least 39% had hypertension, while 13% had diabetes. 61%, were smokers, at least 14.4% reported alcohol use, at least 21% and 26.7% were NSAID and PPI users respectively. The commonest presenting symptoms and indications for gastroscopy were weight loss (71%) and epigastric pain (66.7%). Anaemia was a dominant feature among these patients; 61% had an Hb<12 on presentation, with a mean haemoglobin of 10.6 ± 3.4. 70% of the cohort had associated gastritis, gastric ulcers or duodenitis at endoscopy; the commonest site of gastric pathology was in the corpus (40%). The commonest location of reported GCA was in the lesser curvature (27%), whilst only 6.7% of tumours were in the cardia and fundus. On histology, chronic atrophic gastritis with inflammation was noted in at least 32% of samples. The overall rate of H. pylori on the biopsy specimen was 19% while 54% were H. pylori negative. Conclusion The risk of GCA is higher in adult males above 50years, smokers, with symptoms of epigastric pain, weight loss and anaemia. The high proportion of chronic atrophic